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KMID : 0191120090240050975
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Journal of Korean Medical Science
2009 Volume.24 No. 5 p.975 ~ p.978
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Antibiotic-induced Severe Neutropenia with Multidrug-Dependent Antineutrophil Antibodies Developed in A Child with Streptococcus pneumoniae Infection
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Lee Young-Ho
Lee Ha-Baik
Kim Jung-Yun
Lim Yeon-Jung
Shin Su-A
Han Tae-Hee
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Abstract
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Drug-induced neutropenia (DIN), particularly that in which antibiotic-dependent antineutrophil antibodies have been detected, is a rare disorder. We report the case of a child with pneumococcal pneumonia, who experienced severe neutropenia during various antibiotic treatments. We detected 4 kinds (cefotaxim, augmentin, vancomycin, and tobramycin) of antibiotic-dependent antineutrophil antibodies by using the mixed passive hemagglutination assay (MPHA) technique with this child.
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KEYWORD
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Neutropenia, Antineutrophil Antibody, Anti-Bacterial Agents
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